Paget’s disease of bone

Paget’s disease of bone also called Osteitis Deforms. The disease named after nineteenth century British surgeon, Sir James Paget. It was first described in 1876.

Paget’s disease of bone is a localized or multifocal disorder of bone characterized by abnormal bone turnover with increased osteoplastic bone resorption and compensatory increased osteoblastic activity.

Over time, the body compensates by creating excess periosteum over the affected bones, creating a deformed bony appearance upon x-ray.

This structural change produces bone that is expanded in seize, less compact, more vascular and more susceptible to deformity or fracture than is normal bone.

Paget’s disease is the second-most common bone disorder after osteoporosis in people age 50 and older. 

The disease is frequent in Europe, with the exception of the Scandinavian countries, and is frequent in regions inhabited by European immigrants such as North America and Australia.

It is believed that most patients are symptomatic, but a substantial minority may experience a variety of symptoms, including bone pain, secondary arthritic problems, bone deformity, excessive warmth over bone from hypervascularity, fracture and a variety of neurological complications caused in most instances by compression of neutral tissues adjacent to pagetic bone.
Paget’s disease of bone