Laron syndrome is a disease characterized by resistance to growth hormone (GH) and usually due to mutations within the gene coding the growth hormone receptor (GHR).
It causes dwarfism, obesity and biochemical changes resembling growth hormone deficiency.
The reason is lack of endogenous circulating IGF-I which is dependent hormone.
Clinical features of Laron syndrome including a protruding forehead, and short face with a pug nose. The lower jaw was underdeveloped and the permanent teeth grew irregularity early and were crowded.
The circumference of the head was very small and when viewed form the front, was widest near the top of the skull.
Laron syndrome
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Gastrointestinal infections caused by Clostridium perfringens, termed
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