Cushing’s syndrome is a clinical condition resulting from prolonged exposure to excessive glucocorticoid from either endogenous or exogenous.
In 1927, F. A. Hartman suggested that the general function of the adrenal gland was production of hormone, and in 1929 he demonstrated that adrenal extract sustained life in animals without adrenal gland.
In 1899 William Osler first described what became known s Cushing’s syndrome and the adrenal tumor was confirmed by Parkes-Weber in 1913.
Harvey Cushing, the famed Harvard neurosurgeon, described the first case of Cushing’s syndrome with a severe phenotype in 1912. Since then investigation and management of Cushing’s syndrome has remained a significant clinical challenge.
Cushing’s disease is usually caused by adrenocorticotropic hormone ACTH - secreting pituitary adenoma.
Cushing’s disease accounts for 70% of all cases of Cushing’s syndrome and is due to a microadenoma of the pituitary in over 90% of cases.
Some of the most frequent clinical signs of Cushing’s syndrome, such as obesity, hypertension, and glucose intolerance are also common in hypertensive patients without glucocorticoid excess.
What is Cushing’s syndrome?
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